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To the Editor: Essential thrombocythemia (ET) complicated by cerebral venous sinus thrombosis (CVST) is exceptionally rare. Hitherto, few studies have mentioned the role of Janus kinase 2V617F (JAK2V617F) mutation in ET patients who developed CVST; thus, the strategy and long‐term outcomes are yet rarely reported. The present study documented four cases, wherein CVST was the first manifestation of JAK2V617F‐positive ET.

Cerebral Venous Sinus Thrombosis as the First Manifestation of JAK2V617F -positive Essential Thrombocythemia