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Tumefactive demyelinating lesions (TDLs),[1‐3] previously named as tumor-like inflammatory demyelinating disease[4,5] or demyelinating pseudotumor,[6] are relatively special type of immune-mediated inflammatory demyelinating lesions in the central nervous system (CNS),[7] which mainly occur within cerebrum, but rarely in spinal cord. TDLs are so named because it mimics brain tumors with such characteristics as less severe symptoms, large lesions with perilesional edema, mass effect and/or enhancement on neuroimaging, and easily misdiagnosed as brain tumors.[8,9]

Chinese Guidelines for the Diagnosis and Management of Tumefactive Demyelinating Lesions of Central Nervous System