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Sepsis, which is defined as life‐threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death in the Intensive Care Unit (ICU).[1] Epidemiological studies have shown that the incidence of sepsis has been gradually increasing during the past decades.[2,3] It still remains a major challenge for clinicians to find potential targets to improve the outcome of septic patients.

T-cell Co-inhibitory Molecules in Sepsis-induced Immunosuppression