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Herpes zoster (HZ) is an acute virus infectious disease mainly affecting middle-aged and elderly people. The morbidity rates of HZ in the age group of 50–59 years and 60–69 years are, respectively, 46 and 69 (per year, per 10,000 people). The age groups of 70–79 years and 80–89 years have a much higher rate of 95 and 109 (per year, per 10,000 people), respectively.[1,2] Postherpetic Neuralgia (PHN) is a neuropathic syndrome which manifests as ongoing pain along the cutaneous nerve/s located in the area of prior HZ rash and typically involves one or more of the following types of pain: spontaneous aching or burning; paroxysmal shooting; and allodynia and hyperalgesia. While in the majority of cases, this pain will resolve within a year of initial rash presentation, for some patients the pain may persist for 5 years or more. As expected, given the relationship to HZ, the incidence of PHN increases markedly with age. However, the incidence is also linked to the severity of the pain experienced during the HZ episode. Those patients experiencing the highest levels of acute pain during HZ presentation are most at risk of developing PHN. PHN is also more prevalent among female than male HZ paitents.

A Study on the Connection between the Incidence of Postherpetic Neuralgia and Serum Ionized Calcium