Open AccessReduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan
Author(s) -
P B Mal,
Joveria Farooqi,
Seema Irfan,
Molly A. Hughes,
Erum Khan
Publication year - 2016
Publication title -
indian journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 48
eISSN - 1998-3646
pISSN - 0255-0857
DOI - 10.4103/0255-0857.188338
Subject(s) - chlorhexidine , disinfectant , microbiology and biotechnology , multiple drug resistance , enterobacteriaceae , minimum inhibitory concentration , tertiary care , beta lactamase , antibiotics , biology , medicine , chemistry , veterinary medicine , dentistry , escherichia coli , gene , pathology , biochemistry
We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.
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