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Objective : The study was undertaken to assess the organ directedtoxicity of halquinol in female wistar albino rats. Materials andMethods : Halquinol was administered orally by gavage at the dose of 0(control), 150 (low), 450 (intermediate) and 1000 (high) mg/kg bodyweight daily for a period of 28 days to four groups of rats (n=6). Eachrat was weighed at the beginning and at weekly intervals thereaftertill the end of the study. Blood and serum samples were analyzed on Day0, 14 and 28 for haematological parameters viz, Hb, Hct, TEC, MCV, MCH,MCHC, TLC and DLC and serum biochemical parameters viz, ALP, ALT, AST,TSP, TA, BUN and Creatinine respectively. At the end of the studyorgans were weighed and organ to body weight ratios were calculated.The representative tissue samples were processed for histopathologicalexamination. Results : The body weight in the intermediate and highdose group was significantly (P< 0.01) lower than the control group.The Hb, TEC and MCHC decreased significantly (P< 0.01) whereas MCVincreased significantly (P< 0.01) in high dose group. Serumbiochemical parameters viz, ALP, ALT, BUN and creatinine significantly(P< 0.01) increased in intermediate and high dose groups. Organ tobody weight ratio in case of liver and kidney was also significantly(P< 0.01) higher in high dose group. Histopathology of liver andkidney from intermediate and high dose groups revealed markedpathological alterations. Conclusion : From the present study it wasconcluded that at intermediate and high dose, halquinol was hepatotoxicand nephrotoxic in female rats.

Organ directed toxicity of halquinol in a repeated dose 28 day oral toxicity study in female rats