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The concept of the effect-site concentration of anesthetic agents is important. The effect compartment model can be explained using the concepts of effect-site concentration and effect-site equilibration rate constant ( k  e0 ). This study confirms that the time-to-peak effect ( t pe  ) can be measured easily in clinical practice by applying a priming dose and train-of-four (TOF) during general anesthesia induction, and k  e0 can be calculated from the t pe  of the four muscle relaxants that are commonly used in general anesthesia.

korean journal of anesthesiology

Estimation of the effect-site equilibration rate constant using the time-to-peak effect of muscle relaxants measured by train-of-four stimulation during general anesthesia induction