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Propofol and remifentanil are usually co-administered and have shown synergistic effect for anesthesia. However, the synergistic effect of the two drugs on hypnosis measured by bispectral index (BIS) was controversial in previous studies. The aim of this study was to identify the interaction of propofol and remifentanil on BIS and the optimal dose combinations for hypnosis under 66% N(2)O during surgery.

korean journal of anesthesiology

Interactions of propofol and remifentanil on bispectral index under 66% N<sub>2</sub>O: analysis by dose-effect curve, isobologram, and combination index

Interactions of propofol and remifentanil on bispectral index under 66% N2O: analysis by dose-effect curve, isobologram, and combination index

Interactions of propofol and remifentanil on bispectral index under 66% N₂O: analysis by dose-effect curve, isobologram, and combination index