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Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as oxygen content falls. Leukotrienes constrict smooth muscle and could be important for the regulation of the pulmonary circulation. Hence we hypothesized that ATP and leukotrienes are mediators of HPV produced during acute alveolar hypoxia.

Effects of ATP and LTC4on hypoxic pulmonary vasoconstriction in isolated rat lungs

Effects of ATP and LTC₄on hypoxic pulmonary vasoconstriction in isolated rat lungs