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Neuropathic pain syndromes are caused by damage, disease, or a nervous system dysfunction, usually in the peripheral nervous system. Normally, neuropathic pain sufferers experience spontaneous burning pain in and radiating from the area innervated by the damaged nerves. In addition, they show an exquisite sensitivity to the light touch stimuli (allodynia), and hyperalgesia. The neuropathic pain is usually very difficult to treat once it occurs, 1) and the patient suffers from severe intractable pain. However, it is unclear why some individuals develop pain after losing their afferent input while others with the same degree of deafferentation do not. 2) Furthermore, there are no predictors to indicate which patients will develop neuropathic pain. So, its prevention is very important. Glucocorticoids have anti-inflammatory effects and have been used to treat many types of nerve injury-associated symptoms and complex regional pain syndromes. Among steroids, methylprednisolone is a synthetic steroid with strong glucocorticoid activity. It is commonly used, along with other synthetic steroids, for its anti-inflammatory effects because it is distinguished by the absence of any significant salt-retaining activity. To date, there are few reports concerning the pre-emptive effect on the development of neuropathic pain after nerve Pre-emptive Effect of Methylprednisolone on the Mechanical Allodynia Development after Peripheral Nerve Injuries in Rats