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Backgrounds: L-type voltage-dependent calcium channel (LTCC) plays a crucial role in insulin secretion from pancreatic β cells through Ca2+ influx. In the recent report, LTCC Cav1.3 subtype homozygous knock out mice showed impairment of postnatal pancreatic beta cell development as well as insulin secretion. Methods: We performed 90% partial pancreatectomy in heterozygous Cav1.3 knock out mice to investigate the effect of partial deficiency of Cav1.3 gene on beta cell regeneration in the adult. Glucose homeostasis, metabolic profiles including serum insulin and lipid levels and morphologic changes of pancreatic islets were studied.Results: 90% Partial pancreatectomy induced glucose intolerance only in the heterozygous knock out mice at 8 weeks after surgery. Distribution of islet size was significantly different between two groups after partial pancreatectomy; median value of islet size of heterozygote was larger than that of wild type (642.8 μm2 vs 1459.8 μm2, P

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Proliferation and Differentiation of Pancreatic β Cells in L-type Calcium Channel α1D Subunit (Cav1.3) Heterozygous Knock Out Mice After Partial Pancreatectomy