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The antioxidant N-acetylcysteine is being increasingly investigated as a therapeutic agent in the treatment of substance use disorders (SUDs). This study explored the efficacy of N-acetylcysteine in the treatment of posttraumatic stress disorder (PTSD), which frequently co-occurs with SUD and shares impaired prefrontal cortex regulation of basal ganglia circuitry, in particular at glutamate synapses in the nucleus accumbens.

the journal of clinical psychiatry/the journal of clinical psychiatry

A Double-Blind, Randomized, Controlled Pilot Trial of &lt;em&gt;N&lt;/em&gt;-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders