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History of Ketamine Response by Patient Age/Sex/ Ethnicity Duration of Illness (y) No. of Prior SRI Trials Prior EX/RP Trials KETAMINE Memantine Start ↓ MEMANTINE PreBaseline Y-BOCS Post– 1-Week Y-BOCS Days Post-Ketamine Infusion PreBaseline Y-BOCS Y-BOCS at Dropb Post– 6-Week Y-BOCS Memantine Continuation 12-Weekc Y-BOCS Ketamine responders 1 47/M/AA 19 3 Yes 26 14 84 25 14 22 2 53/M/W 15 1 No 29 12 28 11 12 ...d 3 32/M/H 25 3 Yes 29 17 21 21 19 25 4 24/F/AA 12 0 Yes 25 7 14 0 0 ... ... Ketamine nonresponders 5 24/M/H 5 0 No 24 27 73 27 23 ... 6 32/M/W 11 3 Yes 23 19 62 18 23 ... ... 7 38/F/A 22 2 No 36 31 25 31 28 ... 8 29/F/AA 14 4 No 29 30 14 31 23 ... 9 33/M/W 30 5 No 24 26 14 26 21 ... 10 22/F/AA 10 0 No 25 24 7 24 24 ... ... 11 33/M/AA 21 0 No 20 23 7 23 26 ... 12 36/M/W 20 1 Yes 23 20 7 20 23 ... ... aHistory of ketamine response in a prior study (see Koran et al1) was defined as a ≥ 35% Y-BOCS reduction 1 week after intravenous ketamine. bY-BOCS score at drop visit. Participant 4 dropped at week 4 due to no longer having OCD symptoms. Participants 6, 10, and 12, dropped at week 2 due to increased anxiety. cMemantine was continued to 12 weeks in those with treatment response (see Goodman et al12) either to ketamine (≥ 35% Y-BOCS reduction 1 week after intravenous ketamine) or to memantine (≥ 35% Y-BOCS reduction from pre– to post–6 weeks of memantine). dParticipant 2 reported continued low OCD symptoms while on his medication, but was unable to have week 12 independent evaluation until 2 weeks after his medications ran out. His Y-BOCS score at week 14 independent evaluation was 26. Abbreviations: A = Asian, AA = African American; EX/RP = Cognitive Behavioral Therapy with Exposure and Response Prevention; F = female; H = Hispanic, M = male; OCD = obsessive-compulsive disorder, SRI = serotonin reuptake inhibitor; W = white; Y-BOCS = Yale-Brown Obsessive Compulsive Scale. Symbol: ... = not applicable. Open-Label Trial on the Effects of Memantine in Adults With Obsessive-Compulsive Disorder After a Single Ketamine Infusion