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[page 15] Jeremy Safran made a major contribution to contemporary psychotherapy both as a scientist and as a clinician. This contribution is somehow hard to summarize given the vastness of the issues he explored and drastically affected, and it definitely goes far beyond the research, technical or theoretical fields alone. Safran, indeed, provided us a new conceptualization of psychotherapy work itself, in which the therapist and the patient and their hic et nunc (i.e., here and now) intersubjective dynamics are conceived as the multilevel core of the treatment. This new conceptualization has represented a revolutionary step in the psychotherapy literature, as we outline below. The impact on the literature was reached by continuous and progressive work on the concept of the therapeutic alliance. Therapeutic alliance was previously defined as an interactive process between the patient and the clinician based on their ability to create a respectful and cooperative bond. Safran and Muran (2000) critically refined the concept of alliance by drifting from the construct of “agreement” to the idea of “negotiation” between therapist and patient. Under this view, alliance was no longer conceived as a static dimension necessary to establish an effective intervention but rather as a constantly shifting, emergent property of the therapeutic relationship (Safran & Muran, 2000, 2006). Therefore, therapeutic alliance was interpreted as an intersubjective negotiation process, where rupture moments became the new core element of the therapeutic process. Accordingly, rupture moments were defined as “a breakdown in the collaborative process between therapist and patient, a poor quality of therapistpatient relatedness, a deterioration in the communicative situation, or a failure to develop a collaborative process from the outset” (Safran & Muran, 2006, p. 288). As a consequence, ruptures became an essential element as a “window on the relational schemas of the patient” or, rather, as the opportunity to investigate and better understand the patient’s mental functioning. The types of ruptures (withdrawn or confrontation ruptures) most frequently adopted by the patient reflect his/her coping strategy or a feature of their psychic functioning. As a consequence, correctly identifying ruptures can guide the therapist’s interventions to repair them (Safran & Muran, 2000). Under this framework, the therapeutic process was reformulated as a coparticipation in the therapeutic dyad in the negotiation composed of the continuous sequence of rupture and resolution phenomena. Following this rationale, resolving ruptures implies intervening and reorganizing the relational schemas of the patient (Safran & Muran, 2000); the negotiation process represents, therefore, the therapeutic changing process. Through the therapeutic work on therapeutic alliance, in Safran’s theory, the therapist can intervene on the patient’s interpersonal experience often characterized by maladaptive patterns. This process might lead to a positive “interpersonal cognitive cycle” (Safran & Segal, 1990). The impact of this new conceptualization has been tremendous and is currently reflected at different levels. On a theoretical level, the therapeutic process has been reformulated under an intersubjective perspective as a “specific psychological field” created by the interplay beJeremy Safran’s impact on Italian psychotherapy research and practice: a window into the processes involved in therapeutic alliance