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– After some words on the scientific role of Professor Paolo Mantegazza at the University of Milan (4, 5, 6), I briefly illustrate some studies related to the occurrence of neurotransmitter and receptor re-specification in the adult animals. The great discoveries of the early twentieth century on neuronal communication have established that the majority of communication between nerve cells occurs through a special structure, the synapse, allowing the one-way transfer of information between two cells through the release of a neurotransmitter from the presynaptic cell and its recognition by receptors localized in the postsynaptic cell. According to H. Dale axiom (9) each neuron could be identified on the basis of the neurotransmitter released and the innervated cell by the type of receptors expressed; then neurons could be classified as excitatory if they release acetylcholine, glutamate or other transmitters, or inhibitory if they release GABA or glycine. However, in recent years many studies have shown that, FRANCESCO CLEMENTI 30

LA RISPECIFICAZIONE DEL TRASMETTITORE E DEL RECETTORE È UNA NUOVA FORMA DI PLASTICITÀ DEL SISTEMA NERVOSO NELL’ADULTO