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Nano and micro particles are widely used in industrial, household and medicinal applications. To understand the interaction between particles and epithelial cells, we developed a dynamic model of the alveolar interface. This system, named DALI (Dynamic Model for the ALveolar Interface), is a modular bioreactor composed of two chambers divided by a porous membrane where epithelial lung cells are seeded. The membrane is the support of the alveolar barrier that separates the two compartments of the alveolus: the air and blood side. The system integrates the following elements: i) Air/Liquid interface, thanks to the two chambers divided by the membrane: ii) Cell culture media flow, thanks to the presence of a peristaltic pump; iii) Lung breathing motion, thanks to an airflow that allows the stretching of the membrane; iv) Aerosol deposition system, to study the effects of drug efficacy or particle toxicity on the epithelial layer; v) Quartz Crystal Microbalance, to quantify the amount of aerosolized particles.

Engineering a dynamic model of the alveolar interface for the study of aerosol deposition