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Background: College of Medicine students are at high risk of contracting hepatitis B since they come in contact with infected patients during their training program and are expected to have proper knowledge of the hepatitis B virus infection and know their vaccination status. The aim of the work: To determine the level of knowledge of hepatitis B virus and the vaccination status among college of medicine students in Enugu State, South-East Nigeria. Methods: A school-based descriptive cross-sectional study was carried among college of medicine students at ESUT College of Medicine, Enugu State. A pretested self-administered questionnaire was used to collect information from 437 students. Data analysis was carried out using the Statistical Package for Social Sciences version (SPSS) 22 and a p-value of 0.05 was used to determine statistical significance. Results: The mean age of the respondents was 22.3 ± 3.7 years and the majority were single (91.1%) and female (54.7%). A high proportion (68.2%) of the students had a good knowledge of HBV while a minority (20.0%) were aware of their vaccination status. Lack of vaccination programs for students (36.6%) and poor awareness of HBV vaccine for adults (32.5%) were the commoner reasons for non-vaccination. While final year students, (95% CI=1.73-28.92), respondents who consume herbal concussions (95% CI= 0.98-2.96) and those who were at least 30 years old (95% CI=0.32-5.16) were 7.1, 1.7 and 1.3 times respectively more likely to have good knowledge of HBV disease, females (95% CI=0.30-0.83) and respondents who consumed alcohol (95% CI= 0.32-0.89) were about twice less likely to have poor knowledge of HBV than males and non-alcohol consumers. Conclusion: Although most of the students had a good knowledge of HBV infection their vaccination status was low indicating the need for government to make a policy that would mandate that all college of medicine students should get vaccinated as part of the admission process.

Knowledge of hepatitis B virus infection and vaccination status among college of medicine students in Enugu State, south-east, Nigeria