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Cervical kyphosis may be potentially the most serious and, indeed, a life-threatening manifestation of Larsen syndrome because of the impingement on the spinal cord at the apex of the kyphosis. Abnormalities of the spine, specifically cervicothoracic kyphosis requires specific attention and management.    Case presentation  We report on a 3-year-old boy who presented with full clinical and the radiographic features of Larsen syndrome. There was significant vertebral body hypoplasia of C5/7 combined with spina bifida occulta from C1/T2, resulting in congenital cervical instability and kyphosis.    Conclusion  Congenital or developmental cervical kyphosis is a serious orthopaedic abnormality, which is associated with several syndromic associations such as Larsen syndrome, diastrophic dysplasia, chondrodysplasia punctata, camptomelic dysplasia, and neurofibromatosis.

cases journal

Significant traumatic atrophy of the spinal cord in connection with severe cervical vertebral body hypoplasia in a boy with Larsen syndrome: a case report and review of the literature