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Optimization, scaling and parameter estimation are inverse problems that appear in many biotechnological processes. In the solution of inverse problems, different techniques such as metaheuristics algorithms, have been used. These algorithms efficiently search for and find good solutions to a problem with a reasonable computational cost. In this pape, four well-known metaheuristic algorithms (Genetic Algorithm, Differential Evolution, Ant Colony Optimization and Particle Swarm Optimization) are applied to the problem of parameter estimation in the liquid chromatography separation process. The effectiveness of each method is analyzed and performance comparison based on different statistical criteria is made. The procedure allows to obtain estimated values close to the real parameters, with a good fit of the curves generated by the model to syntetically generated experimental data. The algorithm that performs better is Differential Evolution.

Comparación de diferentes algoritmos metaheurísticos en la estimación de parámetros del modelo relacional general de cromatografía líquida en columna