English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

espanolSe realizo el estudio fitoquimico y la evaluacion de la actividad leishmanicida de la especie Esenbeckia litoralis (Rutaceae) para obtener metabolitos secundarios mayoritarios con potencial biologico. Los extractos obtenidos se fraccionaron empleando tecnicas cromatograficas y los compuestos se identificaron mediante el analisis de datos espectroscopicos: Infrarrojo, Resonancia Magnetica Nuclear y Espectrometria de Masas; la actividad leishmanicida se determino por citometria de flujo y la citotoxicidad por el metodo MTT. Se aislaron e identificaron siete compuestos: Flindersiamina (1), 1-hidroxi-3-metoxi-W-metilacridona (2), Maculosidina (3), Kokusaginina (4), Maculina (5), Dictamina (6) y Gardenina B (7). El compuestos 2 y el subextracto en acetato de etilo de corteza mostraron una moderada actividad frente a Leishmania (V) panamensis con un IC50 de 37.5 y 9.2 μg/ml respectivamente. El estudio muestra la presencia de metabolitos activos con potencial leishmanicida en estos extractos, lo que podria representar una alternativa terapeutica para el tratamiento de la enfermedad parasitaria conocida como leishmaniosis. EnglishA phytochemical study and evaluation of leishmanicidal activity of Esenbeckia litoralis species (Rutaceae) to obtain secondary metabolites with high biological potential were carried out and completed. The obtained extracts were fractionated using chromatographic techniques and the compounds were identified by spectroscopic analysis including infrared, nuclear magnetic resonance and Mass Spectrometry; the leismanicidal activity was determined by flow cytometry and cytotoxicity by MTT method. Seven compounds were isolated and identified: Flindersiamine (1), 1-hydroxy-3-methoxy-W-methylacridone (2), Maculosidine (3), Kokusaginine (4), Maculine (5), Dictamine (6) and Gardenin B (7). The compound 2 and the ethyl acetate extract of bark showed moderate activity against the parasite of Leishmania panamensis with an IC50 = 37.5 and 9.2 μg/ml respectively. The study showed the presence of active metabolites with leishmanicidal potential in these extracts, which could represent an alternative therapy for treatment of the leishmaniasis.

Estudio Fitoquímico y Evaluación del Potencial Leishmanicida de la Especie Esenbeckia litoralis (Rutaceae)