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Mutagenic potential of piroxicam (1), 2-aminopyridine (2), meloxicam (3) and 2-amino-5-methylthiazole (4) has been evaluated using in vivo micronucleus test. Four dose levels for each compound were used and bone marrow cells were examined 24 hours after the administration. In the case of the degradation product of piroxicam (2) only 0.1, 0.3, 1.0 and 5.0 mg/kg were evaluated, because at 50 mg/kg all animals died. The results show that doses applied do not induce a statistical significant increase of the frequency of micronucleated polychromatic erythrocytes. Aniline (5) has been used as positive mutagen reference, showing a positive response to the micronucleous induction at doses of 50mg/kg or superior while no induction occur with lower doses. The structural-mutagenic activity relationship between piroxicam and aniline could not been established.

Evaluación del Potencial Mutagénico de Piroxicam, Meloxicam y Precursores mediante el Ensayo de Micronúcleos in vivo