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In the present work the synthesis of various 4-aryl-2-(coumarin-3-yl)-6-(4-methyl-3-phenyl coumarin-6-yl)pyridines (6a-i) and 4-aryl-2-(coumarin-3-yl)- 6-(4-methyl-7-methoxy coumarin-8-yl)pyridines ( 7a-i) have been carried out by reacting 1-[2( H )-1-benzopyran-3-yl]-3-aryl-prop-2-en-1-ones (coumarinoyl chalcones) ( 3a-f) with appropriate coumarinoyl methyl pyridinium bromide salt 4 and 5 respectively. The target compounds were characterized by the IR, 1 H-NMR, 13 C-APT and mass spectral analysis. Preliminary examination of target compounds as antimicrobial agents has been carried out using Broth dilution method.

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW ASYMMETRICALLY SUBSTITUTED 4-ARYL- 2,6-DI(COUMARINYL) PYRIDINES