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A series of novel 1,3-thiazoles have been synthesized in good yields, using dialkyl acetylenedicarboxylate, benzamide and quinoline derivatives of thiourea in ethanol. Keywords: Thiourea, dimethyl acetylene dicarboxylate, diethyl acetylene dicarboxylate, thiazoline. e-mail: etavakoly@yahoo.com 1. INTRODUCTION Since the past few decades, heterocyclic chemistry has been one of the most important disciplines in organic synthesis and pharmaceutical chemistry 1 . A large numbers of these compounds have emerged as active pharmaceutical ingredients in several drugs for their potential anti-inammatory 2,3 , anti-tumor 4 , anti-hyperlipidemic 5 , anti-hypertensive 6 , anti-HIV infections 7 , and several other biological properties 8,9 .One of the most important groups of five-membered heterocycles including S and N atoms, are thiazolole compounds. Thiazole heterocycle is a component of many natural products and synthetic compounds exhibiting a wide range of biological activity 10-13 . The pharmacological activities and their coordination properties are important features to prepare metal complexes with potential therapeutical activity or as model of metal-enzyme

SYNTHESIS OF NEW 1,3-THIAZOLE DERIVATIVES; USING 1-(4-CARBAMOYLPHENYL)-3-METHYLTHIOUREA AND 1-METHYL-3-(QUINOLIN-8-YL) THIOUREA AS STARTING MATERIALS