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In order to obtain a better tool for collecting forensic evidence at the crime scene and the subsequent analysis of gunshot residue in laboratories, we propose the development of Molecularly Imprinted Polymers (MIPs) for the retention of diphenylamine (DPA), an organic compound coming from gunshot residues. This technique aims to achieve molecular recognition of a particular organic molecule, called target molecule. Once occurred recognition, this organic molecule may be removed, separated, and preconcentrated for further analysis. For this, a series of MIPs and their analogs Non Molecularly Imprinted Polymers (NIPs) following a non-covalent strategy was synthesized. This was carried out by solution radical polymerization, using 1-vinyl-2-pyrrolidone (VP) as monomer, and diphenylamine as imprinting and target molecule. The retention capacity of MIPs was studied by HPLC and UV-VIS spectroscopy, meanwhile adsorption mechanism was studied by isothermal and kinetic assays. Resin yields ranged from 25% to 100%. The results show that the variable that has more influence on DPA retention is the amount of crosslinking, wherein a greater amount of crosslinking results in higher retention of DPA, achieving values up to 90%. There is a clear difference in adsorption capacity between MIPs and NIPs, where MIPs show higher adsorption capacity reaching a double or triple retention value. Kinetic studies show that it is achieved a high retention capacity within 5 min of contact. The results show that the fundamental mechanism for molecular recognition displayed by the imprinting effect can be attributed at two processes: the pre-organization of complementary functional groups present in the polymer and the template and selective cavity formation which complement the template size. Binding factors and selectivity combined effects contributing to molecular recognition of diphenylamine (DPA) by MIPs.

PREPARATION OF MOLECULARLY IMPRINTED POLYMERS FOR DIPHENYLAMINE REMOVAL FROM ORGANIC GUNSHOT RESIDUES