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A simple, sensitive and validated HPLC method has been developed to determine valsartan and ramipril simultaneously in synthetic mixture. Chromatographic separation was achieved on a C-18 column using a mixture of acetonitrile and water in the ratio 55:45 (v/v), pH adjusted to 3.6 with 88% orthophosphoric acid at a wavelength of 215 nm. Linearity of the method was found to be in the concentration range of 50-250 µg/ml for valsartan and100-500 µg/ml for ramipril with correlation coefficient greater than 0.999. The total eluting time for the two components is less than five minutes. The method can be used for simultaneous determination of valsartan and ramipril. Keywords : HPLC, Valsartan, Ramipril e-mail: lakshmiss@hotmail.com INTRODUCTION Valsartan [fig 1] chemically designated as (S)-3-methyl-2-[N({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid belong to angiotensin II receptor antagonist used for the treatment of hypertension 1 . A number of analytical methods have been developed for its determination in pharmaceutical formulations or in biofluids either alone or in combination with other drugs, which includesliquid chromatography-tandem mass spectrometry

A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION