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A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F 254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily resolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective calibration plots were found to be linear over the range 200–1000 and 200–700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation. Keywords: High-performance thin-layer chromatography, telmisartan, atorvastatin calcium e-mail: santoshvgandhi@rediffmail.com INTRODUCTION Atorvastatin calcium (ATV), (βR,dR)-2-(4-fluorophenyl)-β,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-1-heptanoic acid, calcium salt, is a synthetic cholesterol-lowering agent

A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION