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The reaction of cholest-5-en-7-one (1) , its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2’-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4) , 2’-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5) , and 2’-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6) , respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria. Keywords: thiosemicarbazide, pyrazolines, cholest-5-en-7-one, thiocarbamoyl, anti-bacterial activity. e-mail: shams_chem@rediffmail.com INTRODUCTION In recent years, bacterial infections have increased markedly which have caused severe health problems in some subtropical regions of the world. Parasitic bacteria such as Bacillus subtilis, S. pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING