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Reaction of 3-substituted isocoumarins (1a-h) with excess of sodium borohydride in methanol gave the corresponding 2-(2-(hydroxymethyl)phenyl)ethanol derivatives (2a-h). Antimicrobial activities of synthesized compounds were measured, using Gram-negative (Escherichia coli, Salmonella typhi, Proteus mirabilis) and Gram-positive bacteria (Bacillus cereus, Staphylococcus aureus). Key words: Isocoumarin, sodium borohydride, diol, antimicrobial properties. e-mail: nawaz_f@yahoo.co.in. INTRODUCTION Synthesis of variety of compounds like carbocyclic, heterocyclic compounds and various aromatic compounds can be effected from isocoumarins intermediates. 1 The hydroxyl structural moiety was found in numerous pharmaceutically active compounds and therefore represents an interesting template for combinatorial as well as medicinal chemistry. 2 In particular phenylethanol derivatives have good antifungal properties. 3, 4 An increasing number of new isocoumarins in nature and increasing importance of diol derivatives have stimulated our researcher group a continued interest for synthesis of 2-(2-(hydroxymethyl)phenyl)ethanols from the precursor isocoumarins. Recently, several methods have been reported for the synthesis of diols such as palladium catalyzed reactions, electrophilic aromatic substitution, cyclization of 2-allyl- and alkenyl benzoic acid, etc.

SYNTHESIS OF 2-(2-(HYDROXYMETHYL)PHENYL)ETHANOL DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS