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A facile synthesis of an array of 6,7-fused steroidal thiazoles (4-9) is reported. Replacement of lachrymatory 7-bromosteroidal ketones (4a) with readily accessible 5-bromosteroidal ketones (1-3), as a starting material, on simple condensation with thiourea or phenylthiourea gives the thiazole fused ring products. The products have been characterized on the basis of microanalytical and spectral data, which nd support in some cases from comparison with previously known samples. A rationalization for the routes of conversion is given, based on current and previous results. Keywords: Steroidal thiazoles, lachrymatory, phenylthiourea, IR spectroscopy.INTRODUCTIONThiazole is an important heterocycle found in various natural products, notably thiamine (vitamin B). 1 Therefore, thiazole derivatives have been isolated and synthesized in view of their pharmacological activities viz antibacterial, antifungal, anti-inammatory and antiviral. 2-6 These are also employed as antiallergic,

A FACILE SYNTHESIS OF 6,7-FUSED STEROIDAL THIAZOLES VIA 1,3-INTRAMOLECULAR MIGRATION OF BROMINE/ALLYLIC DISPLACEMENT OF BROMINE