English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Since the biological activity of [Ru III (NH 3 ) 4 (catechol)] + has never been tested, its cytotoxicity to glial cells was assayed and correlated with its redox properties. Coordinated catechol oxidizes faster than catechol in the presence of oxygen, but controlled potential electrolysis showed that its oxidation involves only one-electron. However, the oxidation of the free ligand by oxygen involves two electrons, which could generate more reactive oxygen species. Indeed, catechol was more cytotoxic than [Ru III (NH 3 ) 4 (catechol)] + complex to human glioblastoma GL-15 cells and also to rat astrocytes. [Ru III (NH 3 ) 4 (catechol)]-induced cytotoxicity was related to the generation of reactive oxygen species and [Ru II (NH 3 ) 4 (quinone)] 2+ . However, other mechanisms should be involved since antioxidant enzymes and deferoxamine only partially protected GL-15 cells. INTRODUCTION Ruthenium is an element that has industrial, pharmaceutical and medical applications. Ruthenium can be used in the reduction of noxious oxides from industrial emissions

REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS