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Over dose or long-term clinical use of therapeutic doses of acetaminophen (APAP) causes hepatotoxicity. Various strategies attempted to ameliorate APAP-hepatotoxicity have been found to be unsuitable for clinical practice. This study was a imed to illustrate the histopathological changes induced by therapeutic dose of APAP and investigate the hepatoprotective role of oral coadministration of selenium/ Tribulus terrestris (TT) extract concurrently against hepatotoxicity induced by APAP in rats. Fifty-four healthy male albino Wistar rats were randomized into nine groups (G1–G9) of six rats each, and administered with APAP and TT or ally for 30 days as follows: Control (2ml normal saline), APAP (470 mg/kg), APAP (470 mg/kg) + selenium (2 mg/kg), APAP (470 mg/kg) + TT (98 mg/kg), APAP (470 mg/kg) + selenium (2mg/kg) + TT (98 mg/kg), APAP (470 mg/kg) + silymarin (200 mg/kg), selenium (2 mg/ kg), TT (98 mg/kg) and silymarin (200 mg/kg) groups. The results demonstrated that exposure of rats to therapeutic dose of APAP for 30 days caused significant histopathological changes parallel to elevated blood chemistry parameters. Coadministration of seleni um/TT extract showed significantly reduced histopathological lesions and, restored or decreased levels of the examined blood chemistr y parameters. Liver histology in selenium/TT extract showed normal hepatic architecture with mild changes and silymarin treated rats showed n o histopathological changes. Histochemically PAS staining, showed that APAP-induced hepatotoxicity was characterized by hepatocyt es glycogen depletion. Selenium/TT co-supplementation plays a potential role in preventing APAP-induced glycogen depletion by incr easing detoxification and scavenging the reactive metabolites. Selenium/TT extract oral co-administration possesses a significant hepa toprotective property and mitigates APAP-induced hepatotoxicity by enhancing its antioxidant role and improving tissue integrity. Selenium/T T supplementation could represent an effective treatment against APAP-induced hepatotoxicity. Further studies are needed to eluci date the exact mechanism underlying the protective role of TT extract.

international journal of morphology

Hepatotoxicity-Induced by the Therapeutic Dose of Acetaminophen and the Ameliorative Effect of Oral Co-administration of Selenium/Tribulus terrestris Extract in Rats