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Honey is a natural antioxidant that its protective effects have been proven against ischemia-reperfusion (IR) injury. The aim of this study was to evaluate the ameliorative effect of Persian Honey, Apis mellifera meda skorikov, on gastro cnemius muscle IR injury. Eighty adult male Sprague–Dawley rats weighing 250–300 g were used. They were divided into ten groups (N=8 pe r group). The ischemia was conducted with a silk suture 6-0 using the slipknot technique. All groups were rendered in ischemic fo r 3 , and reperfused for various times of 3 days (3-day reperfusion), 7 days (7-day reperfusion), 14 days (14-day reperfusion), and 28 da ys (28-day reperfusion). Half of the groups had experimental honey (5 %) treatment immediately after ischemia. After reperfusion, the rats , bas d on the grouping, were killed with high doses of anesthetic, and the gastrocnemius muscles were removed and fixed. After the tis sue processing, the evaluation of edema and mast cells infiltration was performed with hematoxylin-eosin and toluidine blue stainin g, respectively. TNFα was detected with immunohistochemistry method. The amount of TNFα as an index of acute inflammatory except the 3rd day significantly decreased on the other day of reperfusion ( , 14 and 28 days). The mast cells infiltration was significantly decreased on 7 7th and 14 days. The tissue edema was decreased significantly in honey administrated group in the comparison with placebo groups. Honey administration can reduce damage caused by ischemia-reperfusion in the rat gastrocnemius muscle.

Protective Effects of Honey, Apis mellifera Meda Skorikov, on Ischemia-Reperfusion Induced Muscle Injury