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Acute effect of purified mimosine (MiMo) extracted from Leucaena leucocephala on testicular histopathology has been documented with seminal vesicle (SV) atrophy. Since protein phosphorylation and seminal secretions play important roles in sperm physiology, this study aimed to study the alteration of substances including tyrosine phosphorylated (TyrPho) proteins in semin al vesicle treated with MiMo. Male mice were divided into a control and experimental groups treated with purified MiMo at 3 doses of 15, 3 0, and 60 mg/KgBW, respectively for 35 consecutive days. The morphology and weights of SV were compared among groups. The levels of magnesium and fructosamine in SV fluid were assayed. The profiles of equally SV total proteins were compared using SDS-PAGE. Th e expression of seminal TyrPho proteins was detected by western blotting. Recent results showed the decreased weights of SV in Mi M treated mice compared to control. However MiMo in all doses did not affect the levels of magnesium and fructosamine in SV fluid . The SV protein expression of 130 and 55 kDas was obviously decreased in a high dose MiMo. In dose-dependent response, the expressio ns of 72 and 55 kDas TyrPho proteins of SV were increased. In conclusion, MiMo could affect SV morphological size and protein secr etions especially TyrPho proteins.

Mimosine Increases the Expressions of Tyrosine Phosphorylated Protein in Mouse Seminal Vesicles