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Cerebral Palsy (CP) refers to chronic childhood encephalopathy. The objective of this study was to verify effects of CP model that combines prenatal exposure to LPS, perinatal anoxia and sensorimotor restriction on EDL muscle. Male Wistar ra t pups were separated: a) Control pups of mothers injected with saline during pregnancy and b) Cerebral Palsy pups of mothers inje cted with LPS during pregnancy, and submitted to perinatal anoxia and sensorimotor restriction. The CP group presented hypertrophy in the ty e IIB fibers and increase of nuclei/fiber and capillary/fiber ratios. The intrafusal fibers of CP group presented 26 % atrophy in the crosssectional area and intramuscular collagen volume increase 34 %. CP group showed myofibrillar disruption and Z-line disorganizat ion and the NMJs presented increases of 22 % in area.This animal model of CP produces motor deficits and macro and microscopic alte rations and in the ultrastructure of the EDL muscle.

An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle