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SUMMARY: The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, severalauthors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly: liver,lungs and kidneys. But, the majority of the works are done with the application of dexamethasone in the late periods of pregnancy.Because of the lack of researches that evaluate the effects in the beginning of gestation, this paper aimed at evaluating the effect ofdexamethasone administered in the initial phase of pregnancy, over the morphology of neonates rat. It was used 10 albino rats (Rattusnorvegicus albinus) aged 90 days from the lineage Wistar. The female were coupled and divided in two groups: Group I – rats notsubmitted to the dexamethasone application (control); Group II – rats submitted to the dexamethasone application in the first 5 days ofpregnancy. The results show that the treatment with dexamethasone in a dosage of 0.8mg/Kg during the 5 first days of pregnancy does notproduces a weight and height reduction or malformation in the offspring, it does not cause changes in the development of the liver andkidneys of neonate rats, but it leads to a reduction in the denseness of the interalveolar septa causing a higher distension of the alveoli.

Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy