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Bone morphogenetic proteins (BMPs) stimulate regeneration of bone and cartilage (Jortikka et al., 1993a,b; Cook, 1999; Govender et al., 2002; Wozney, 2002; Cheng et al., 2003). The bone-healing properties of different recombinant and extracted BMPs have been studied using long bone defect models in rabbits (Hollinger et al., 1998; Kokubo et al., 2003), dogs (Tuominen et al., 2000), rats (Matsuo et al., 2003) and sheep (Gao et al., 1997). Favorable results in preclinical and clinical trials have also led to the regulatory approval of different commercial recombinant BMP products for some clinical purposes by government agencies (Matsuo et al.). Considering that there are about 30 BMPs known, products consisting of single recombinant BMPs cannot be regarded as being ideal. Also, our knowledge of their long-term effects and of how safe they are is still limited. BMPs occur as a mixture in living organisms, and native BMPs are also a mixture when extracted. Thus, studies aiming at safe and effective products from native BMPs are still needed.

Newly Formed Bone in Mandible Decortication Experimental Model Using rhBMP-2 Evaluated by Densitometric Study