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− Chungpesagan-tang (CST) has been traditionally used in Korea as a therapeutic for cerebralischemia. To understand the protective mechanism of CST on hypoxia/reoxygenation insults in N2a cells, thecell viability was determined with the treatment of water solution and several solvent fractions of CST. The high-est cell viability occurred when the cells were treated with the hexane soluble fraction of CST. Hypoxia/reoxy-genation insults were shown to decrease the glutathione peroxidase (GPx) activity and the level of glutathione(GSH) and increase the superoxide dismutase (SOD) activity. However, treatment with hexane soluble fractionof CST ranging from 0.1 µg/ml to 10 µg/ml recovered the activities of GPx and SOD and maintained the levelsof MDA and GSH at control levels. While hypoxia/reoxygenation insults induced the activation of ERK in N2acells, treatment with the hexane soluble fraction of CST inhibited the activation of ERK in a concentrationdependent manner. In this study, we were able to demonstrate that the bioactive compounds of CST can beeffectively transferred into the hexane soluble fraction, and more importantly that CST exhibits protective effectsagainst hypoxia/reoxygenation insults most likely by recovering redox enzyme activities.

Hexane Soluble Fraction of Chungpesagan-tang Exhibits Protective Effect against Hypoxia/Reoxygenation-Induced N2a Cell Damage