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− Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-canceractivities. In this study, we examined the regulatory activity of G-Rp1 on the functional activation of macroph-ages. G-Rp1 remarkably inhibited TNF-α production, LPS-induced cell cytotoxicity, NO production, ROS gener-ation, and phagocytic uptake from lipopolysacchride (LPS)-activated RAW264.7 cells. According to structuralfeature study using several G-Rp1 analogs, two carbohydrates (glucose-glucose) at R1 position were observedto be highly effective, compared to other structural derivatives. Although the inhibitory activities of G-Rp1 onmacrophage functions were not remarkable, several points that G-Rp1 was known to be safe, and that thiscompound was orally effective, suggest that G-Rp1 may be beneficial in treating macrophage-mediated immu-nological diseases. Keywords: Ginseng saponin, Macrophage function, RAW264.7 cells, Immunological disease, Inflammation INTRODUCTION Macrophages are a type of differentiated tissue cellsthat originate from blood monocyte. The cells have sev-eral functions such as 1) killing the pathogenic microor-ganisms; and 3) the phagocytic uptake and processing/presentation of antigens ingested to lymphocytes (Kinne

Inhibitory Effect of Ginsenoside-Rp1, a Novel Ginsenoside Derivative, on the Functional Activation of Macrophage-like Cells