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− The pharmacokinetic parameters and bioavailability of pranoprofen from the gel were measured todetermine the enhancing effect of octanoic acid on the transdermal absorption of pranoprofen in rats. 8 mg/kgof pranoprofen was administered from gel with octanoic acid (the enhancer group) or that without octanoic acid(the control group) via the transdermal route, and the results were compared with those obtained from the intra-venously (0.5 mg/kg, IV group) or orally administered group (4 mg/kg, oral group). The AUC of the control, theenhancer, the IV, and the oral groups were 20.2±5.1, 50.7±12.7, 19.9±2.5, and 70.5±17.6 u g/ml · h respectively.The average C max of the control and the enhancer group were 0.93±0.23 and 2.82±0.71 u g/ml, respectively,and the mean T max of the control and the enhancer group was 7.00 h. The relative bioavailability of the trans-dermally administered pranoprofen gel containing octanoic acid was approximately 2.50 times higher than thecontrol group, showing a relatively constant, sustained blood concentration with minimal fluctuation. This sug-gests that it might be feasible to develop a pranoprofen gel preparation containing an enhancer for the transder-mal administration, which is more convenient dosage form than the oral dosage forms.

Enhanced Bioavailability by Transdermal Administration of Pranoprofen Gels Containing Octanoic Acid to Rats