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We investigated the minimum killing concentrations of chlorhexidine gluconate (CHG) and olanexidine gluconate (OLN) on clinically isolated Staphylococcus aureus strains. The concentration of CHG that inhibited growth of 50% of S. aureus strains (MKC50) was 0.1250%; the concentration that inhibited growth of 90% strain (MKC90) was 0.5000%. For OLN, MKC50 was 0.0020% and MKC90 was 0.0156%. Of the 137 strains, 18 strains (13.7%) had the qacA/B gene, the increase in MKC by holdings qacA/B was not observed. OLN showed bactericidal effect at low concentration compared with CHG.

The Minimum Killing Concentrations of Chlorhexidine Gluconate and Olanexidine Gluconate on Clinically Isolated <i>S.aureus</i> Strains