English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

DC-SIGN (DC-speciˆc intercellular adhesion molecule-3-grabbing nonintegrin), which is a type II transmembrane C-type lectin expressed on dendritic cells (DCs), recognizes cell-surface carbohydrates on invading pathogens such as bacteria and viruses and plays an important role in the uptake and presentation of these antigens. To date, little is known about the correlation of DCSIGN with cancer. Recently, we reported that DC-SIGN bound to colorectal carcinoma cells by recognizing colorectal tumor-associated Lewis (Le) glycan ligands. The interaction of DC-SIGN with colorectal cancer cells increased LPS-induced IL-6 and IL-10 secretion from monocyte-derived DCs (MoDCs), resulting in inhibition of the maturation of MoDCs and diŠerentiation of naä ƒve T cells into Th1 cells. Furthermore, DC-SIGN-expressing cells were shown to colocalize with colorectal cancer-associated Le glycan ligands in primary colon cancer tissues. These results indicate that DC-SIGN-mediated dysfunction of DCs in tumor immunity is one of the critical mechanisms for escaping immune surveillance. A. Introduction DCs play professional roles in recognizing foreign antigens and inducing a T-cell dependent immune response during the shift from innate immunity to acquired immunity (1–3). DCs are the main component of the immune system for an eŠective response, therefore a defect of DC function may trigger breakdown of the whole immune system (4). It has been reported recently that pathogens such as viruses and tumor cells target DCs to escape from the host immune sytstem (5). Among a variety of receptors expressed on DCs, the C-type lectin receptor (CLR) family, like the Toll-like receptor (TLR) family, comprises a series of pathogen

Colorectal carcinoma-associated carbohydrate recognition and tumor-immunological regulation by C-type lectin DC-SIGN