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Background: Recently, results of many trials that intend to decide the axillary status through more conservative procedures are reported. One of these is sentinel node biopsy. This method is regarded as reasonable and selective. Some investigators tend to omit axillary dissection in the patient who is determined to have negative node clinically and negative result in sentinel node biopsy procedure. This study was designed to know how accurate the sentinel node biopsy method can predict axillary nodal status. Materials and Methods: The patients group was selected from Department of Surgery at SMC, consisting of 11lpa~ients with surgically curable breast cancer from Sept. 1995 to Apr. 1997. Isosulfan blue was injected in the center of mass and the margins of 4 quadrant under the general anesthesia. Axillary dissection was done 5 minutes after injection to identify the stained lymphatics. When stained lymphatics were identified, dissection was performed along the lymphatics bidirectionally to detect the stained lymph node nearest to the primary tumor (sentinel node). After frozen biopsy of sentinel node, routine axillary node dissection was performed. Results of frozen biopsy were compared with the final pathologic results. Results: Sentinel node was detected in 80 of the III cases (72.1 %) and there were 44 (55.0%) axillary metastasis cases in sentinel node detection group. In 14 of 44 cases, sentinel node was isolated positive node. In 5 of 44, sentinel node were falsely negative for malignancy. Sensitivity and specificity of the method are 88.6% (39/44), 100% (36/36), respectively. Conclusions: Sentinel node biopsy method can predict the axillary nodal status in patients with breast cancer. This method can lead to more conservative treatment, eventually omitting axillary nodal dissection in selected patients. (Korean J of Breast Cancer 1998;1:39--44)

Effectiveness of Sentinel Node Biopsy in the Prediction of Axillary Nodal Status in 111 Patients with Breast Cancer