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The high mobility group box 1 (HMGB1) protein has roles in apoptosis and immune responses by acting as a ligand for receptor for advanced glycation end products (RAGE), Toll-like receptors (TLRs), and triggering receptor expressed on myeloid cells 1. In particular, HMGB1/RAGE is involved in tumor metastasis by inducing matrix metalloproteinase 2 (MMP2) and MMP9 expression. We investigated the associations between genetic variations in HMGB1 -related genes and disease-free survival (DFS) and overall survival (OS) in Korean female breast cancer patients.

Genetic Predisposition of Polymorphisms inHMGB1-Related Genes to Breast Cancer Prognosis in Korean Women