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Plasminogen activator inhibitor type 1 (PAI-1), an important regulator of plasminogen activator system which controls degradation of extracellular membrane and progression of tumor cells, and PAI-1 gene polymorphic variants have been known as the prognostic biomarkers of non-small cell lung cancer patients. Recently, experimental in vitro study revealed that transforming growth factor-β1 initiated PAI-1 transcription through epithelial growth factor receptor (EGFR) signaling pathway. However, there is little clinical evidence on the association between PAI-1 A15T gene polymorphism and prognosis of Korean population with pulmonary adenocarcinoma and the influence of activating mutation of EGFR kinase domain.

tuberculosis and respiratory diseases

Plasminogen Activator Inhibitor Type 1 (<i>PAI-1</i>) A15T Gene Polymorphism Is Associated with Prognosis in Patients with<i>EGFR</i>Mutation Positive Pulmonary Adenocarcinoma

Plasminogen Activator Inhibitor Type 1 (PAI-1) A15T Gene Polymorphism Is Associated with Prognosis in Patients withEGFRMutation Positive Pulmonary Adenocarcinoma