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The role of antisperm-antibodies (ASA) as a cause of human infertility was recognized with evidence provided by research through last few decades. It is established that ASA can negatively impact fertility by affecting sperm motility, cervical mucus penetration, gamete fusion and potentially even the first steps of embryo development1. ASA can be found in systemically (in blood and lymph) and in local secretions (in semen, oviductal, uterine, cervicalvaginal and follicular fluid)2,3. The three major structural types of antisperm immunoglobulins are IgA, IgG and IgM2. With the development and the encouraged use of accurate and easy assays for the screening of ASA and the progress in assisted reproductive technologies (ART), the role of ASA in infertility as well as the potential for their treatment is becoming better defined3. It is believed that the degree of sperm-autoimmunization is the main empirical criterion in choosing more or less invasive ART procedures for couples with ASA3. In-vitro fertilization (IVF) with conventional IVF/intra-cytoplasmic sperm injection (ICSI), bypasses most, if not all, of the steps in conception that are adversely affected by ASA in human infertility1,4. We report three cases of infertile couples who demonstrated a high level of antisperm antibodies, and were successful in achieving pregnancies following in-vitro fertilization (IVF). Apart from infertility, those couples were otherwise healthy and free of any significant illnesses. The ASA were detected using mixed agglutination reaction latex bead test (SpermMAR, Fertipro NV, Belgium).

Successful pregnancy outcomes following in-vitro fertilization in infertile couples with high levels of antisperm antibodies