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Palmyrah flour which is consumed by humans in some Asian and African countries, has previously been reported to produce acute and chronic toxic effects in rats. This report describes the characteristics of neoplasms which developed in rats which were either fed directly on a 20% flour diet or were theoffspring of palmyrah fed females. Single or multiple malignant lymphomas of varying degrees of differentiation were the commonest tumour; their predominant location was the Small intestinal mesentery. Thymic and pulmonary lymphomas and lymphomatous nodules attached to the spleen and kidney were also present in some of these cases. A cervical fibrosarcoma and an intra-abdominal tumour of possibly pancreatic origin were also included in this series. Hind limb paralysis was observed in three tumour bearing rats, one of which had an atrophic spinal cord. The toxic effects of this flour, notably aberrations of immune competence, are discussed in relation to : h e pathogenesis of these tumours with special reference t o a possible aetiological role of C-type viruses.

journal of the national science foundation of sri lanka/journal of the national science foundation

Studies on the toxicology of the palmyrah palm (&lt;em&gt;Borassus flabellifer&lt;/em&gt; L.) Part III. Development of malignant lymphomas in rats after prolonged feeding of palmyrah flour.