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Platypnoea-orthodeoxia syndrome (POS) is a rare condition in which hypoxaemia and breathlessness occur when upright and resolve when prone. POS has been reported in association with intracardiac and intrapulmonary shunting. This case describes a patient who presented with hypoxaemia and platypnoea and investigations showed an interatrial defect with right to left shunt, without pulmonary hypertension. DOI: 10.4038/cmj.v55i4.2635 Ceylon Medical Journal 2010; 55: 131-132

Platypnoea-orthodeoxia syndrome due to right to left interatrial shunting despite normal intracardiac pressures