English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Schiff base ligands, having nitrogen and oxygen donor sites and their zinc (II) complexes have been prepared by using methanol as a solvent. Purity of the compounds has been tested by TLC and are characterized by FT-IR, multinuclear NMR ( 1 H and 13 C). FT-IR spectra suggested the binding of precursors and their chelation with zinc (II) moieties by showing characteristics peaks in particular regions. 1 H-NMR also approves the synthesis of compounds by showing characteristics peaks of azomethine proton (HC=N) and phenolic proton (-OH). On complexation phenolic proton was disappeared while a down field shift was observed in azomethine proton. 13 C-NMR data further supports the formation of compounds by the displaying and shifting of characteristic peaks of azomethine carbon (HC=N).The DNA binding ability of all the synthesized ligands was studied by UV-Visible spectroscopy. A hypochromic affect was observed showing that ligands interacted with DNA by intercalation. The results implied that these synthesized compounds can be employed for the formulation of Anticancer and Antitumor drugs in future with less toxic side effects to normal cells (unlike toxic drugs presently used) .Moreover they were found to have antifungal and antibacterial activity by Disc Diffusion method. Zinc containing complexes have been investigated a lot recently for the treatment of Diabetes Mellitus. Thus, these synthesized compounds are potential drug candidates for research if explored .

Synthesis, Spectroscopic Characterization and Biological Applications of Novel Zinc Complexes with Schiff Bases