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The biotechnological value of macroalgae for screening assays of thrombin generation-TG using sulfated polysaccharides-SPs as substitutes to heparin has been poorly explored. Five Brazilian species of macroalgae ( Gracilaria birdiae , Acanthophora muscoides , Halymenia sp., Caulerpa cupressoides and C. racemosa ) were analyzed and compared for their abundance, physical-chemical characteristics and in vitro anticoagulant assays of activated partial thromboplastin time-APTT, prothrombin time-PT and TG. Papain extraction yielded (p 100 kDa. These procedures, combined with the use of Stains-All, also indicated nonSPs. APTTs ranged from 2.81 ( A. muscoides ) to 21.30 IU ( Halymenia sp.) vs. heparin (193 IU), and were dependent on sulfation of the crude SPs. PT was not altered. With respect to TG assay, crude SPs modified concentration-dependent and independently from molecular mass TG by both intrinsic/extrinsic pathways in 60-fold diluted human plasma, with total intrinsic inactivation using crude SPs from A. muscoides in parallel to heparin (p < 0.05). Thrombosis in vitro is differentially modulated by distinct crude SPs from Brazilian seaweeds.

acta scientiarum biological sciences

&lt;b&gt;Extraction, physical-chemical characterization and &lt;i&gt;in vitro&lt;/i&gt; inhibitory potential of thrombin generation of crude sulfated polysaccharides from Brazilian tropical seaweeds