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Neste trabalho investigamos a influência da Gymnema sylvestre (Gs) na elevação da lipidemia após administração de gordura de origem animal em ratos machos Wistar (230g - 250g). Os animais, em jejum por 22 horas, foram divididos em 5 grupos que receberam via intragástrica às 8h os seguintes tratamentos: 1) 2mL de gordura suína Batavo®/kg de peso corpóreo (GSB); 2) GSB + 500mg/kg de peso corpóreo de Gs (Gs 500mg); 3) GSB + 1g/kg de peso corpóreo de Gs (Gs 1g); 4) Gs 500mg; 5) Gs 1g. Os animais foram sacrificados 30min após a administração destas substâncias. Não observamos diferenças significativas na concentração sérica de lipídeos totais, triglicerídeos e colesterol total nos ratos que receberam GSB na ausência ou presença de Gs 500mg ou Gs 1g. Portanto, nossos resultados sugerem que a Gs não afeta a absorção intestinal de lipídeos The aim of the present experiment was to investigate the influence of Gymnema sylvestre (Gs) on the elevation of blood levels of lipids after administration of animal fat in male Wistar rats (230–250g). The animals, which were fasted for 22h, were separated in five groups that received (8:00 a.m) intragastric administration of: 1) 2ml of pork fat Batavo® /kg of body weight (PFB); 2) PFB+500mg/kg of Gs body weight (Gs 500mg); 3) PFB + 1g/kg of Gs body weight (Gs 1 g); 4) Gs 500mg; 5) Gs 1g. The animals were sacrificed 30min after the administration of these substances. No significant differences were verified in the serum concentration of total lipids, triglycerides and cholesterol in the animals, which received PBF in the presence or absence of Gs 500mg or Gs 1g. Therefore, the results showed that Gs could not affect the intestinal absorption of lipid

Efeito da Gymnema sylvestre na elevação da lipidemia após administração de gordura de origem animal em ratos wistar